MASP-1

位於3號人類染色體的基因

甘露糖結合凝集素絲氨酸蛋白酶1 (Mannan-binding lectin serine protease 1,也被稱為 甘露糖相關絲氨酸蛋白酶1,mannose-associated serine protease 1,縮寫MASP-1)是由人類基因 MASP1 編碼的一種[1][2][3]

Mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
有效結構
PDB 直系同源檢索:PDBe, RCSB
標識
代號 MASP1; 3MC1; CRARF; CRARF1; MAP1; MASP; MASP3; MAp44; PRSS5; RaRF
擴展標識 遺傳學600521 同源基因89143 GeneCards: MASP1 Gene
EC編號 3.4.21.-
直系同源體
物種 人類 小鼠
Entrez 5648 n/a
Ensembl ENSG00000127241 n/a
UniProt P48740 n/a
mRNA序列 NM_001031849 n/a
蛋白序列 NP_001027019 n/a
基因位置 Chr 3:
187.22 – 187.29 Mb
n/a
PubMed查詢 [1] n/a

MASP-1參與補體系統的凝集素途徑,負責的切割C4C2形成C4b2a,作為C3-轉化酶參與下一步的反應。[4]

另見

參考文獻

  1. ^ A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum. Biochemical and Biophysical Research Communications. Oct 1993, 196 (2): 1003–9. PMID 8240317. doi:10.1006/bbrc.1993.2349. 
  2. ^ Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein. International Immunology. Apr 1994, 6 (4): 665–9. PMID 8018603. doi:10.1093/intimm/6.4.665. 
  3. ^ Entrez Gene: mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor). 
  4. ^ Proteolytic activities of two types of mannose-binding lectin-associated serine protease. Journal of Immunology. Sep 2000, 165 (5): 2637–42 [2016-11-24]. PMID 10946292. doi:10.4049/jimmunol.165.5.2637. (原始內容存檔於2009-01-09). 

外部連結

MASP-1引用了美國國家醫學圖書館提供的資料,這些資料屬於公共領域