促甲状腺激素β亚基

Thyroid stimulating hormone, beta
促甲状腺激素β亚基
Thyroid stimulating hormone, beta; 促甲状腺激素β亚基
标识
代号	TSHB; TSH-B; TSH-BETA
扩展标识	遗传学：188540 鼠基因：98848 同源基因：463 GeneCards: TSHB Gene
基因本体论描述
分子功能	· hormone activity;
细胞成分	· extracellular region;
生物过程	· G-protein coupled receptor signaling pathway; · cell-cell signaling; · anatomical structure morphogenesis; · peptide hormone processing; · response to vitamin A; · response to estrogen stimulus; · cellular protein metabolic process; · response to calcium ion;
	Sources: Amigo / QuickGO
直系同源体
物种	人类
Entrez	7252
Ensembl	ENSG00000134200
UniProt	P01222
mRNA序列	NM_000549
蛋白序列	NP_000540
基因位置	Chr 1:; 115.57 – 115.58 Mb
PubMed查询	[1]
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促甲状腺激素β亚基（英語：Thyroid stimulating hormone, beta，简称TSHB）是一个由人类基因TSHB 编码的蛋白质^[1]^[2]。

功能

促甲状腺激素（TSH）是由两个亚基非共价连接而成的糖蛋白，其α亚基为该类激素所共有，而β亚基则是独有的^[3]。

另见

促甲状腺激素

参考文献

^ Wondisford FE, Radovick S, Moates JM, Usala SJ, Weintraub BD. Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species. J. Biol. Chem. September 1988, 263 (25): 12538–42 [2014-03-29]. PMID 2457586. （原始内容存档于2020-04-25）.
^ Tatsumi K, Hayashizaki Y, Hiraoka Y, Miyai K, Matsubara K. The structure of the human thyrotropin beta-subunit gene. Gene. December 1988, 73 (2): 489–97. PMID 3243440. doi:10.1016/0378-1119(88)90513-6.
^ Entrez Gene: TSHB. （原始内容存档于2010-04-12）.

延伸阅读

Bonomi M, Proverbio MC, Weber G; et al. Hyperplastic pituitary gland, high serum glycoprotein hormone alpha-subunit, and variable circulating thyrotropin (TSH) levels as hallmark of central hypothyroidism due to mutations of the TSH beta gene.. J. Clin. Endocrinol. Metab. 2001, 86 (4): 1600–4. PMID 11297590. doi:10.1210/jc.86.4.1600.
Vuissoz JM, DeladoÃ«y J, Buyukgebiz A; et al. New autosomal recessive mutation of the TSH-beta subunit gene causing central isolated hypothyroidism.. J. Clin. Endocrinol. Metab. 2001, 86 (9): 4468–71. PMID 11549695. doi:10.1210/jc.86.9.4468.
Karges B, LeHeup B, Schoenle E; et al. Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe.. Horm. Res. 2004, 62 (3): 149–55. PMID 15297803. doi:10.1159/000080071.
Kabadi UM, Premachandra BN. Serum thyrotropin in Graves' disease: a more reliable index of circulating thyroid-stimulating immunoglobulin level than thyroid function?. Endocr Pract. 2007, 13 (6): 615–9. PMID 17954417.
Miyai S, Yoshimura S, Iwasaki Y; et al. Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line.. Cell Tissue Res. 2005, 322 (2): 269–77. PMID 16133148. doi:10.1007/s00441-005-0033-z.
Pierce JG. Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones.. Endocrinology. 1971, 89 (6): 1331–44. PMID 5002675. doi:10.1210/endo-89-6-1331.
Atzmon G, Barzilai N, Surks MI, Gabriely I. Genetic Predisposition to Elevated Serum Thyrotropin Is Associated with Exceptional Longevity. J. Clin. Endocrinol. Metab. 2009, 94 (12): 4768–75. PMC 2795660  . PMID 19837933. doi:10.1210/jc.2009-0808.
Landa I, Ruiz-Llorente S, Montero-Conde C; et al. Gibson, Greg , 编. The Variant rs1867277 in FOXE1 Gene Confers Thyroid Cancer Susceptibility through the Recruitment of USF1/USF2 Transcription Factors. PLoS Genet. 2009, 5 (9): e1000637. PMC 2727793  . PMID 19730683. doi:10.1371/journal.pgen.1000637.
Pohlenz J, Dumitrescu A, Aumann U; et al. Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the TSHbeta-subunit gene. J. Clin. Endocrinol. Metab. 2002, 87 (1): 336–9. PMID 11788671. doi:10.1210/jc.87.1.336.
Miyoshi I, Kasai N, Hayashizaki Y. [Structure and regulation of human thyroid-stimulating hormone (TSH) gene]. Nippon Rinsho. 1994, 52 (4): 940–7. PMID 8196184.
Borck G, Topaloglu AK, Korsch E; et al. Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin-beta gene: phenotypic variability and founder effect. J. Clin. Endocrinol. Metab. 2004, 89 (8): 4136–41. PMID 15292359. doi:10.1210/jc.2004-0494.
Comings DE, Gade-Andavolu R, Gonzalez N; et al. A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory. Clin. Genet. 2000, 58 (5): 375–85. PMID 11140838. doi:10.1034/j.1399-0004.2000.580508.x.
Gerhard DS, Wagner L, Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928  . PMID 15489334. doi:10.1101/gr.2596504.
Clark AG, Glanowski S, Nielsen R; et al. Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. Science. 2003, 302 (5652): 1960–3. PMID 14671302. doi:10.1126/science.1088821.
Loinder K, Söderström M. An LXXLL motif in nuclear receptor corepressor mediates ligand-induced repression of the thyroid stimulating hormone-beta gene. J. Steroid Biochem. Mol. Biol. 2005, 97 (4): 322–7. PMID 16216492. doi:10.1016/j.jsbmb.2005.06.031.
Luttrell LM. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. Mol. Biotechnol. 2008, 39 (3): 239–64. PMID 18240029. doi:10.1007/s12033-008-9031-1.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (26): 16899–903. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899.
Brumm H, Pfeufer A, Biebermann H; et al. Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect. J. Clin. Endocrinol. Metab. 2002, 87 (10): 4811–6. PMID 12364478. doi:10.1210/jc.2002-020297.
Benhadi N, Wiersinga WM, Reitsma JB; et al. Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death. Eur. J. Endocrinol. 2009, 160 (6): 985–91. PMID 19273570. doi:10.1530/EJE-08-0953.
Schaefer JS, Klein JR. A novel thyroid stimulating hormone β-subunit isoform in human pituitary, peripheral blood leukocytes, and thyroid. Gen. Comp. Endocrinol. 2009, 162 (3): 241–4. PMC 2689139  . PMID 19364510. doi:10.1016/j.ygcen.2009.04.006.

促甲状腺激素β亚基引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

[pmid2457586-1] Wondisford FE, Radovick S, Moates JM, Usala SJ, Weintraub BD. Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species. J. Biol. Chem. September 1988, 263 (25): 12538–42 [2014-03-29]. PMID 2457586. （原始内容存档于2020-04-25）.

[pmid3243440-2] Tatsumi K, Hayashizaki Y, Hiraoka Y, Miyai K, Matsubara K. The structure of the human thyrotropin beta-subunit gene. Gene. December 1988, 73 (2): 489–97. PMID 3243440. doi:10.1016/0378-1119(88)90513-6.

[entrez-3] Entrez Gene: TSHB. （原始内容存档于2010-04-12）.

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