1-羟基菲
化合物
1-羟基菲（英語：1-Hydroxyphenanthrene）或叫1-羟菲，是一种菲酚和菲的人体代谢物，可以在暴露于多环芳香烃的人的尿液中检测到。[1]
| 1-羟基菲 | |
|---|---|
| |
| IUPAC名 Phenanthren-1-ol 菲-1-酚 | |
| 别名 | 1-菲酚 1-菲醇 1-羟基菲 1-羟菲 |
| 识别 | |
| CAS号 | 2433-56-9 
|
| PubChem | 98490 |
| ChemSpider | 88945 |
| SMILES |
|
| 性质 | |
| 化学式 | C14H10O |
| 摩尔质量 | 194.23 g·mol⁻¹ |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
它还可以用作海洋鱼胆汁中多环芳香烃污染的标记物。[2]
在菲生物降解的情况下，模型真菌雅致小克银汉霉产生1-羟基菲（菲1-O-β-葡萄糖）的糖苷共轭物。[3]
与吸烟的关系
对于2-、3-和4-羟基菲和1-羟基芘，发现了与每天吸食的香烟有关的高度显着差异和剂量反应关系，但对于1-羟基菲则没有。[4]
参考资料
- ^ PAH metabolites (1-hydroxyphenanthrene, 4-hydroxyphenanthrene, 9-hydroxyphenanthrene, 1-hydroxypyrene). The MAK Collection for Occupational Health and Safety, Biomonitoring Methods, Vol. 6 (article （页面存档备份，存于互联网档案馆）)
- ^ PAH Metabolites in Bile Fluids of Dab (Limanda limanda) and Flounder (Platichthys flesus): Spatial Distribution and Seasonal Changes. Ulrike Kammann, Environmental Science and Pollution Research - International, March 2007, Volume 14, Issue 2, pages 102-108, doi:10.1065/espr2006.05.308
- ^ Cerniglia, C. E.; Campbell, W. L.; Freeman, J. P.; Evans, F. E. Identification of a novel metabolite in phenanthrene metabolism by the fungus Cunninghamella elegans. Applied and Environmental Microbiology. 1989, 55 (9): 2275–2279. PMC 203068
. PMID 2802607. doi:10.1128/AEM.55.9.2275-2279.1989.
- ^ Urinary monohydroxylated phenanthrenes and hydroxypyrene – the effects of smoking habits and changes induced by smoking on monooxygenase-mediated metabolism. Heudorf U and Angerer J, International Archives of Occupational and Environmental Health, April 2001, Volume 74, Issue 3, pages 177-183, doi:10.1007/s004200000215
