ALC-0315是一种合成脂,为油状物质。它是BioNTech辉瑞SARS-CoV-2疫苗BNT162b2疫苗赋形剂,为脂质纳米颗粒(LNP)的四成分之一,LNP封装并保护了药物中脆弱的有效成分mRNA。[2][3]

ALC-0315
IUPAC名
[(4-Hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate)
识别
CAS号 2036272-55-4  checkY
PubChem 122666778
ChemSpider 103867294
SMILES
 
  • CCCCCCCCC(CCCCCC)C(=O)OCCCCCCN(CCCCO)CCCCCCOC(=O)C(CCCCCC)CCCCCCCC
性质
化学式 C48H95NO5
摩尔质量 766.27 g·mol−1
密度 0.919±0.06 g·cm−3(20 °C)[1]
溶解性 7.7×10−5 g·L−1(25 °C)[1]
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

在体内pH下,ALC-0315带正电荷,它可以和带负电荷的mRNA相互作用。[4]这些纳米颗粒在体外和体内都可以促进核酸(如寡核苷酸信使RNA)的吸收。[5][6]

合成

ALC-0315的合成方法如下:

 

参见

参考文献

  1. ^ 1.0 1.1 Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 ([C] 1994-2021 ACD/Labs). Retrieved from SciFinder.
  2. ^ Michael McCoy. Lipids, the unsung COVID-19 vaccine component, Get Investment. Chemical and Engineering News. February 12, 2021. 
  3. ^ Ryan Cross. Without These Lipid Shells, There Would Be No mRNA Vaccines for COVID-19. Chemical & Engineering News. 2021: 16–19. doi:10.47287/cen-09908-feature1. 
  4. ^ Medicines and Healthcare products Regulatory Agency. Public Assessment Report: Authorisation for Temporary Supply COVID-19 mRNA Vaccine BNT162b2 (PDF). 11 December 2020 [2021-05-30]. (原始内容 (PDF)存档于2020-12-16). 
  5. ^ mRNA-based therapeutics — developing a new class of drugs页面存档备份,存于互联网档案馆), Ugur Sahin, Katalin Karikó and Özlem Türeci, Nature Reviews Drug Discovery, 13, 759-780 (2014), doi:10.1038/nrd4278.
  6. ^ mRNA vaccines — a new era in vaccinology页面存档备份,存于互联网档案馆), Norbert Pardi, Michael J. Hogan, Frederick W. Porter and Drew Weissman, Nature Reviews Drug Discovery, 17, 261-279 (2018), doi:10.1038/nrd.2017.243.

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