ALC-0315是一種合成脂,為油狀物質。它是BioNTech輝瑞SARS-CoV-2疫苗BNT162b2疫苗賦形劑,為脂質納米顆粒(LNP)的四成分之一,LNP封裝並保護了藥物中脆弱的有效成分mRNA。[2][3]

ALC-0315
IUPAC名
[(4-Hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate)
識別
CAS號 2036272-55-4  checkY
PubChem 122666778
ChemSpider 103867294
SMILES
 
  • CCCCCCCCC(CCCCCC)C(=O)OCCCCCCN(CCCCO)CCCCCCOC(=O)C(CCCCCC)CCCCCCCC
性質
化學式 C48H95NO5
摩爾質量 766.27 g·mol−1
密度 0.919±0.06 g·cm−3(20 °C)[1]
溶解性 7.7×10−5 g·L−1(25 °C)[1]
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

在體內pH下,ALC-0315帶正電荷,它可以和帶負電荷的mRNA相互作用。[4]這些納米顆粒在體外和體內都可以促進核酸(如寡核苷酸信使RNA)的吸收。[5][6]

合成

ALC-0315的合成方法如下:

 

參見

參考文獻

  1. ^ 1.0 1.1 Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 ([C] 1994-2021 ACD/Labs). Retrieved from SciFinder.
  2. ^ Michael McCoy. Lipids, the unsung COVID-19 vaccine component, Get Investment. Chemical and Engineering News. February 12, 2021. 
  3. ^ Ryan Cross. Without These Lipid Shells, There Would Be No mRNA Vaccines for COVID-19. Chemical & Engineering News. 2021: 16–19. doi:10.47287/cen-09908-feature1. 
  4. ^ Medicines and Healthcare products Regulatory Agency. Public Assessment Report: Authorisation for Temporary Supply COVID-19 mRNA Vaccine BNT162b2 (PDF). 11 December 2020 [2021-05-30]. (原始內容 (PDF)存檔於2020-12-16). 
  5. ^ mRNA-based therapeutics — developing a new class of drugs頁面存檔備份,存於互聯網檔案館), Ugur Sahin, Katalin Karikó and Özlem Türeci, Nature Reviews Drug Discovery, 13, 759-780 (2014), doi:10.1038/nrd4278.
  6. ^ mRNA vaccines — a new era in vaccinology頁面存檔備份,存於互聯網檔案館), Norbert Pardi, Michael J. Hogan, Frederick W. Porter and Drew Weissman, Nature Reviews Drug Discovery, 17, 261-279 (2018), doi:10.1038/nrd.2017.243.

外部連結