吉法酯

化合物

吉法酯(英语:Gefarnate,或译为合欢香叶酯)是一种用于治疗胃及十二指肠溃疡的药物[1],也可用于治疗干眼症[2][3]

吉法酯
Skeletal formula
Space-filling model
临床资料
AHFS/Drugs.com国际药品名称
ATC码
识别信息
  • (2E)-3,7-dimethylocta-2,6-dien-1-yl (4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoate
CAS号51-77-4  checkY
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.000.111 编辑维基数据链接
化学信息
化学式C27H44O2
摩尔质量400.637 g/mol
3D模型(JSmol英语JSmol
  • CC(C)=CCC/C(C)=C/CC/C(C)=C/CCC(=O)OC/C=C(C)/CCC=C(C)C
  • InChI=1S/C27H44O2/c1-22(2)12-8-14-24(5)16-10-17-25(6)18-11-19-27(28)29-21-20-26(7)15-9-13-23(3)4/h12-13,16,18,20H,8-11,14-15,17,19,21H2,1-7H3/b24-16+,25-18+,26-20+ ☒N
  • Key:ZPACYDRSPFRDHO-ROBAGEODSA-N ☒N

参考文献

  1. ^ Ohta Y, Kobayashi T, Imai Y, Inui K, Yoshino J, Nakazawa S. Effect of gefarnate on acute gastric mucosal lesion progression in rats treated with compound 48/80, a mast cell degranulator, in comparison with that of teprenone. Biol. Pharm. Bull. August 2005, 28 (8): 1424–30 [2019-12-20]. PMID 16079487. doi:10.1248/bpb.28.1424. (原始内容存档于2019-08-30). 
  2. ^ Peral A, Domínguez-Godínez CO, Carracedo G, Pintor J. Therapeutic targets in dry eye syndrome. Drug News Perspect. April 2008, 21 (3): 166–76. PMID 18560615. 
  3. ^ Gipson IK, Hori Y, Argüeso P. Character of ocular surface mucins and their alteration in dry eye disease. Ocul Surf. April 2004, 2 (2): 131–48 [2019-12-20]. PMID 17216084. doi:10.1016/s1542-0124(12)70149-0. (原始内容存档于2020-05-20).