含EGF模块黏液素样激素受体

含EGF模块黏液素样激素受体或全称含表皮生长因子模块黏液素样激素受体(英语:Epidermal growth factor module-containing Mucin-like hormone Receptor),缩写为EMR,是G蛋白偶联受体密切相关的亚组。这些受体具有独特的混合结构,其中细胞外表皮生长因子(EGF)样结构域通过黏液素(又叫黏蛋白)样茎与G蛋白偶联受体结构域融合。[1][2][3][4]EMR有四种标记为1-4的变体,每种变体均由单独的基因编码。这些受体主要在免疫系统细胞中表达并结合CD55等配体。[5]

含EGF模块黏液素样激素受体1英语EMR1
识别
符号 EMR1
替换符号 TM7LN3
IUPHAR  EMR1
Entrez 2015
HUGO 3336
OMIM 600493
RefSeq NM_001974
UniProt Q14246
其他资料
基因座 19 p13.3
含EGF模块黏液素样激素受体2英语EMR2
识别
符号 EMR2
IUPHAR  EMR2
Entrez 30817
HUGO 3337
OMIM 606100
RefSeq NM_152916
UniProt Q9UHX3
其他资料
基因座 19 p13.1
含EGF模块黏液素样激素受体3英语EMR3
识别
符号 EMR3
IUPHAR  EMR3
Entrez 84658
HUGO 23647
OMIM 606101
RefSeq NM_032571
UniProt Q9BY15
其他资料
基因座 19 p13.1
含EGF模块黏液素样激素受体4伪基因
识别
符号 EMR4P
替换符号 GPR127
Entrez 326342
HUGO 19240
RefSeq XM_940358
UniProt Q86SQ3
其他资料
基因座 19 p13.3

参考资料

  1. ^ Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M. EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments. Genomics. 1995, 26 (2): 334–44. PMID 7601460. doi:10.1016/0888-7543(95)80218-B. 
  2. ^ Lin HH, Stacey M, Hamann J, Gordon S, McKnight AJ. Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97. Genomics. 2000, 67 (2): 188–200. PMID 10903844. doi:10.1006/geno.2000.6238. 
  3. ^ Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ. Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. J. Biol. Chem. 2001, 276 (22): 18863–70. PMID 11279179. doi:10.1074/jbc.M101147200. 
  4. ^ Caminschi I, Vandenabeele S, Sofi M, McKnight AJ, Ward N, Brodnicki TC, Toy T, Lahoud M, Maraskovsky E, Shortman K, Wright MD. Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE. DNA Seq. 2006, 17 (1): 8–14. PMID 16753812. S2CID 11216477. doi:10.1080/10425170500355737. 
  5. ^ Kwakkenbos MJ, Kop EN, Stacey M, Matmati M, Gordon S, Lin HH, Hamann J. The EGF-TM7 family: a postgenomic view. Immunogenetics. 2004, 55 (10): 655–66. PMID 14647991. S2CID 28689160. doi:10.1007/s00251-003-0625-2. 

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