含EGF模塊黏液素樣激素受體

含EGF模塊黏液素樣激素受體或全稱含表皮生長因子模塊黏液素樣激素受體(英語:Epidermal growth factor module-containing Mucin-like hormone Receptor),縮寫為EMR,是G蛋白偶聯受體密切相關的亞組。這些受體具有獨特的混合結構,其中細胞外表皮生長因子(EGF)樣結構域通過黏液素(又叫黏蛋白)樣莖與G蛋白偶聯受體結構域融合。[1][2][3][4]EMR有四種標記為1-4的變體,每種變體均由單獨的基因編碼。這些受體主要在免疫系統細胞中表達並結合CD55等配體。[5]

含EGF模塊黏液素樣激素受體1英語EMR1
識別
符號 EMR1
替換符號 TM7LN3
IUPHAR  EMR1
Entrez 2015
HUGO 3336
OMIM 600493
RefSeq NM_001974
UniProt Q14246
其他資料
基因座 19 p13.3
含EGF模塊黏液素樣激素受體2英語EMR2
識別
符號 EMR2
IUPHAR  EMR2
Entrez 30817
HUGO 3337
OMIM 606100
RefSeq NM_152916
UniProt Q9UHX3
其他資料
基因座 19 p13.1
含EGF模塊黏液素樣激素受體3英語EMR3
識別
符號 EMR3
IUPHAR  EMR3
Entrez 84658
HUGO 23647
OMIM 606101
RefSeq NM_032571
UniProt Q9BY15
其他資料
基因座 19 p13.1
含EGF模塊黏液素樣激素受體4偽基因
識別
符號 EMR4P
替換符號 GPR127
Entrez 326342
HUGO 19240
RefSeq XM_940358
UniProt Q86SQ3
其他資料
基因座 19 p13.3

參考資料

  1. ^ Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M. EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments. Genomics. 1995, 26 (2): 334–44. PMID 7601460. doi:10.1016/0888-7543(95)80218-B. 
  2. ^ Lin HH, Stacey M, Hamann J, Gordon S, McKnight AJ. Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97. Genomics. 2000, 67 (2): 188–200. PMID 10903844. doi:10.1006/geno.2000.6238. 
  3. ^ Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ. Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. J. Biol. Chem. 2001, 276 (22): 18863–70. PMID 11279179. doi:10.1074/jbc.M101147200. 
  4. ^ Caminschi I, Vandenabeele S, Sofi M, McKnight AJ, Ward N, Brodnicki TC, Toy T, Lahoud M, Maraskovsky E, Shortman K, Wright MD. Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE. DNA Seq. 2006, 17 (1): 8–14. PMID 16753812. S2CID 11216477. doi:10.1080/10425170500355737. 
  5. ^ Kwakkenbos MJ, Kop EN, Stacey M, Matmati M, Gordon S, Lin HH, Hamann J. The EGF-TM7 family: a postgenomic view. Immunogenetics. 2004, 55 (10): 655–66. PMID 14647991. S2CID 28689160. doi:10.1007/s00251-003-0625-2. 

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