BJAB
BJAB是对人类疱疹病毒第四型呈阴性的人类伯基特淋巴瘤细胞系，最初是分离自一名五岁的非洲女性伯基特淋巴瘤患者[1]。然而BJAB细胞衍生而来的GC-BJAB细胞对人类疱疹病毒第四型呈阳性，并且不同于BJAB培养物在达到最大密度后很快就会凋亡，GC-BJAB培养物达到细胞饱和密度后可以长时间维持在存活状态[2]。由于已经确定了两种细胞系的同一性[3]，其生长特性的显著差异须归因于EBV基因组。
抑制
有研究指出[4]，高浓度及长时间的白藜芦醇作用会使BJAB细胞的形态发生改变，不仅胞体变为纺锤形且两极尖细，还使细胞质变得浑浊，甚至出现核固缩或细胞核溶解的情况，干扰着BJAB细胞的细胞周期。原因是白藜芦醇能够抑制DNA复制过程所需的拮抗雌激素及BJAB细胞自分泌的活性氧[5]，从而抑制BJAB细胞的增殖。
参考资料
- ^ Klein, G; Lindahl, T; Jondal, M; Leibold, W; Menézes, J; Nilsson, K; Sundström, C. Continuous lymphoid cell lines with characteristics of B cells (bone-marrow-derived), lacking the Epstein-Barr virus genome and derived from three human lymphomas.. Proceedings of the National Academy of Sciences of the United States of America. 1974-08, 71 (8): 3283–6 [2019-12-08]. PMID 4369887. doi:10.1073/pnas.71.8.3283.
- ^ Steinitz, M; Klein, G. Comparison between growth characteristics of an Epstein--Barr virus (EBV)-genome-negative lymphoma line and its EBV-converted subline in vitro.. Proceedings of the National Academy of Sciences of the United States of America. 1975-09, 72 (9): 3518–20 [2019-12-08]. PMID 171663. doi:10.1073/pnas.72.9.3518.
- ^ Menezes, J; Leibold, W; Klein, G; Clements, G. Establishment and characterization of an Epstein-Barr virus (EBC)-negative lymphoblastoid B cell line (BJA-B) from an exceptional, EBV-genome-negative African Burkitt's lymphoma.. Biomedicine / [publiee pour l'A.A.I.C.I.G.] 1975-07, 22 (4): 276–84 [2019-12-08]. PMID 179629.
- ^ 何广辉. 白藜蘆醇對淋巴瘤細胞作用機制的研究. 2008 [2019-12-08]. doi:10.7666/d.y1407216. （原始内容存档于2019-12-08）.
- ^ Liu, Z; Li, Y; Yang, R. Effects of resveratrol on vascular endothelial growth factor expression in osteosarcoma cells and cell proliferation.. Oncology letters. 2012-10, 4 (4): 837–839 [2019-12-08]. PMID 23205110. doi:10.3892/ol.2012.824.