BJAB
BJAB是對人類皰疹病毒第四型呈陰性的人類伯基特淋巴瘤細胞系，最初是分離自一名五歲的非洲女性伯基特淋巴瘤患者[1]。然而BJAB細胞衍生而來的GC-BJAB細胞對人類皰疹病毒第四型呈陽性，並且不同於BJAB培養物在達到最大密度後很快就會凋亡，GC-BJAB培養物達到細胞飽和密度後可以長時間維持在存活狀態[2]。由於已經確定了兩種細胞系的同一性[3]，其生長特性的顯著差異須歸因於EBV基因組。
抑制
有研究指出[4]，高濃度及長時間的白藜蘆醇作用會使BJAB細胞的形態發生改變，不僅胞體變為紡錘形且兩極尖細，還使細胞質變得渾濁，甚至出現核固縮或細胞核溶解的情況，干擾著BJAB細胞的細胞週期。原因是白藜蘆醇能夠抑制DNA複製過程所需的拮抗雌激素及BJAB細胞自分泌的活性氧[5]，從而抑制BJAB細胞的增殖。
參考資料
- ^ Klein, G; Lindahl, T; Jondal, M; Leibold, W; Menézes, J; Nilsson, K; Sundström, C. Continuous lymphoid cell lines with characteristics of B cells (bone-marrow-derived), lacking the Epstein-Barr virus genome and derived from three human lymphomas.. Proceedings of the National Academy of Sciences of the United States of America. 1974-08, 71 (8): 3283–6 [2019-12-08]. PMID 4369887. doi:10.1073/pnas.71.8.3283.
- ^ Steinitz, M; Klein, G. Comparison between growth characteristics of an Epstein--Barr virus (EBV)-genome-negative lymphoma line and its EBV-converted subline in vitro.. Proceedings of the National Academy of Sciences of the United States of America. 1975-09, 72 (9): 3518–20 [2019-12-08]. PMID 171663. doi:10.1073/pnas.72.9.3518.
- ^ Menezes, J; Leibold, W; Klein, G; Clements, G. Establishment and characterization of an Epstein-Barr virus (EBC)-negative lymphoblastoid B cell line (BJA-B) from an exceptional, EBV-genome-negative African Burkitt's lymphoma.. Biomedicine / [publiee pour l'A.A.I.C.I.G.] 1975-07, 22 (4): 276–84 [2019-12-08]. PMID 179629.
- ^ 何廣輝. 白藜蘆醇對淋巴瘤細胞作用機制的研究. 2008 [2019-12-08]. doi:10.7666/d.y1407216. （原始內容存檔於2019-12-08）.
- ^ Liu, Z; Li, Y; Yang, R. Effects of resveratrol on vascular endothelial growth factor expression in osteosarcoma cells and cell proliferation.. Oncology letters. 2012-10, 4 (4): 837–839 [2019-12-08]. PMID 23205110. doi:10.3892/ol.2012.824.